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Supplementary file Figure 1 confirms a positive correlation between exposure to Compulsory Schooling Laws (CSLs) and community education level

Renal biopsy specimens taken from cigarette smokers showed a range of long-term changes with varying degrees of glomerulosclerosis, ischemic glomeruli, interstitial fibrosis and tubular atrophy, and arteriolar hyalinosis [16], This broad spectrum of histologic findings combined with initial renal hyperfiltration suggested that cigarette smoking induced renal damage was primarily the result of alterations of renal hemodynamics and its sequelae on glomerular and tubular function /structure [17,18,19]

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Ideal temperature for storing tobacco is between 60F and 70F